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Technical Information Magazine 202303-02 Ion Mobility Mass Spectrometer

This presentation introduces the features of the ion mobility mass spectrometer introduced at the Toray Research Center, along with examples of disulfide bond position analysis and glycan structure analysis.

The technical information magazine The TRC News provides the latest information on analytical techniques that are useful for research and development, solving production troubles, and quality control. [Abstract] Ion mobility mass spectrometry can separate structural isomers with the same mass that traditional mass spectrometers cannot, making it promising for various applications such as characterization of antibody drugs and ADCs, glycan structure analysis, binding site analysis, peptide mapping, impurity analysis of nucleic acid drugs, bioanalysis of oligonucleotides, and comprehensive analysis of biomarkers. This article introduces the features of the ion mobility mass spectrometer introduced at the Toray Research Center and presents examples of disulfide bond position analysis and glycan structure analysis. [Table of Contents] 1. Introduction 2. Overview of the Analytical Method 3. Analytical Examples 4. Conclusion

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